Many start-ups do not survive the first few years of business. Previous studies suggest that networks play a role in the success of start-ups, but this positive effect has its limits. The aim of this article is to respond to the demand for a better understanding of the darker side of networks and the variables that condition the probability of survival of start-ups. Based on an empirical study carried out in two different countries, the results show that effective networking depends on the economic situation and creative potential of the start-up company.